Reishi: The Mushroom of Immortality

Posted by Emily van Oosterom on

Reishi, scientifically known as Ganoderma lucidum, is a medicinal mushroom that has been revered in Asian cultures for thousands of years. It's often referred to as the "Mushroom of Immortality" due to its purported health benefits, which include supporting the immune system, promoting longevity, and reducing stress. Today, we're going to delve into the world of Reishi, exploring its history, traditional uses, and most notably, the science that lends credence to its impressive health benefits.

Historical and Traditional Uses

In traditional Chinese medicine, Reishi has been used for over 2000 years, touted as a tonic for enhancing vitality and promoting longevity. Its usage wasn't limited to China; Japan and Korea also recognised the health benefits of this unique fungus. In these cultures, Reishi was used to treat a variety of conditions, including liver disorders, hypertension, arthritis, and even to prevent or treat cancer.

Current Uses

Today, Reishi's popularity extends globally, with research suggesting that it could support immune health, provide antioxidant protection, promote cardiovascular health, reduce fatigue, improve mood and perhaps even extend lifespan. Reishi is available in several forms, including teas, tinctures, and capsules, making it accessible and convenient for consumers.

Chemical Constituents and Actions

The power of Reishi lies in its complex chemical structure, which includes several bioactive compounds. Among the most studied are polysaccharides, triterpenes, and peptidoglycans.

  1. Polysaccharides: These complex carbohydrates have been linked to immune-modulating effects. They act by enhancing the activity of the immune system when it needs a boost and downregulating it when it's overactive. The β-D-glucans, a type of polysaccharide found in Reishi, are particularly adept at this. They bind to receptors on immune cells, including macrophages and natural killer cells, effectively "training" these cells to respond more efficiently to invading pathogens.
  2. Triterpenes: Also known as ganoderic acids, these compounds have been associated with anti-inflammatory, antihypertensive, and liver-protective effects. They work by inhibiting the release of histamine and other pro-inflammatory mediators, thereby mitigating inflammation. Some triterpenes have also demonstrated the ability to inhibit angiotensin-converting enzyme (ACE), which helps control blood pressure and prevent damage to the cardiovascular system.
  3. Peptidoglycans: These compounds, also known as fungal immunomodulatory proteins (FIPs), have been shown to stimulate the immune system and may also have anti-cancer properties.

Scientific Studies

Numerous studies have been conducted to validate the traditional uses of Reishi and explore its potential health benefits further. In a review of 5 randomised controlled trials involving cancer patients, supplementation with Reishi enhanced immune response (Jin et al., 2016).

In another study, Reishi extract was found to improve quality of life in those with neurasthenia, a condition characterised by fatigue, headaches, and feelings of depression (Tang et al., 2005).

Precautions and Contraindications

Reishi is generally considered safe for most people. However, it may interact with certain medications, including anticoagulants and chemotherapeutic drugs. 

Reishi's rich history, combined with the wealth of scientific evidence supporting its health benefits, makes it a powerhouse among medicinal mushrooms. Its multifaceted support for our bodies, particularly its immune-modulating effects, make it a potent ally for health and well-being. As always, it's essential to remember that while Reishi has much to offer, it's not a panacea. It should be used as part of a balanced, health-conscious lifestyle that includes a nutritious diet, regular exercise, and adequate rest.

However, for those interested in natural approaches to health, Reishi can be a fascinating addition to your wellness toolbox. Its long history of use in traditional medicine, combined with the growing body of modern scientific research, suggests that the "Mushroom of Immortality" may indeed have profound benefits for our health and longevity. Remember to consult with a healthcare provider before starting to use Reishi or any other herbal supplement.


  1. Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2016 Jun 13;(6):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27302061.
  2. Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou S. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food. 2005 Spring;8(1):53-8. doi: 10.1089/jmf.2005.8.53. PMID: 15857210.
  3. Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9.
  4. Paterson RRM. Ganoderma - A therapeutic fungal biofactory. Phytochemistry. 2006 Sep;67(18):1985-2001. doi: 10.1016/j.phytochem.2006.07.004. Epub 2006 Aug 14. PMID: 16905165.
  5. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2012 Feb 1. PMID: 22408387; PMCID: PMC3292407.

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